Extended Infusion of Prophylactic Mesna Along with CTLA4Ig in Post-Transplantation Cyclophosphamide Based-Haploidentical Transplantation Is Associated with Reduced Incidence of BK Viruria and Hemorrhagic Cystitis
نویسندگان
چکیده
منابع مشابه
Quantification of polyoma BK viruria in hemorrhagic cystitis complicating bone marrow transplantation.
Polyoma BK virus (BKV) is frequently identified in the urine of bone marrow transplantation (BMT) patients with hemorrhagic cystitis (HC). However, viruria is common even in asymptomatic patients, making a direct causative role of BKV difficult to establish. This study prospectively quantified BK viruria and viremia in 50 BMT patients to define the quantitative relationship of BKV reactivation ...
متن کاملBK virus-associated hemorrhagic cystitis after pediatric stem cell transplantation
Hemorrhagic cystitis is a common stem cell transplantation-related complication. The incidence of early-onset hemorrhagic cystitis, which is related to the pretransplant conditioning regimen, has decreased with the concomitant use of mesna and hyperhydration. However, late-onset hemorrhagic cystitis, which is usually caused by the BK virus, continues to develop. Although the BK virus is the mos...
متن کاملHemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type.
BACKGROUND Hemorrhagic cystitis is a common cause of morbidity after allogeneic stem cell transplantation, frequently associated with BK virus infection. We hypothesized that patients with positive BK viruria before unrelated or mismatched related donor allogeneic hematopoietic stem cell transplantation have a higher incidence of hemorrhagic cystitis. DESIGN AND METHODS To test this hypothesi...
متن کاملBK Virus-associated Hemorrhagic Cystitis in Patients with Allogeneic Hematopoietic Cell Transplantation: Report of Three Cases
BK viras is a human polyoma viras. It is acquired in early childhood and remains life-long latent in the genitourinary system. BK virus replication is more common in receiving immunosuppressive therapy receiving patients and transplant patients. BK virus could cause hemorrhagic cystitis in patients with allogeneic stem cell transplantation. Hemorrhagic cystitis is a serious complication of hema...
متن کاملAn overview of conditioning regimens for haploidentical stem cell transplantation with post-transplantation cyclophosphamide.
Haploidentical related donors are an attractive alternative source of stem cells for allogeneic stem cell transplantation due to widespread availability and ease of stem cell procurement. Historically, haploidentical stem cell transplantation (HaploSCT) with extensive T-cell depletion has been associated with high rates of infectious complications and nonrelapse mortality (NRM). Post-transplant...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2020
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2019.12.671